Capturing a moment in time?
以下是上面那句話的背景：
The big question that remains for all new sequence capture approaches is what will happen if developers finally reach the point where an entire genome can be sequenced for $1,000 or less?“This is something that I think about everyday,something everyone working in this area has to think about,” says NimbleGen’s Zhang.
Most developers suspect the future of sequence capture and enrichment will come down to a simple matter of economics.“I think in one or two years from now
you will be able to sequence one megabase for less than $5,” says Staehler,which he suspects will enable targeted resequencing studies examining tens of thousands of samples.And these studies with their tremendous sample numbers will generate different sets of data than sequencing only a small number of complete genomes for the same price tag.
“As sequencing becomes much higher-throughput and lower-cost,capture has to catch up and become cheaper as well to enable low-cost capture.If the cost of capture is 10–100 times less,then there will always be a niche,” suspects Zhang.Although
he does add that just how big that niche will be remains to be seen.
Others are more doubtful about the future of capture and enrichment for next-generation sequencing.“This will not last forever; it is a transient moment,but what is hard to say is if it will go on for one year or five years,” says Shendure.Although lingering questions about the longevity of sequence-capture approaches remain,there is no questioning the value of the technologies to many researchers at the moment.