be familiar with 一般是指某人熟悉某人、某物：
例句：
I'm not familiar with this computer.我不熟悉這臺(tái)電腦.
Oh,at the end some songs that everyone's familiar with,then they can join in.噢,在晚會(huì)快要結(jié)束時(shí)來幾首大家都熟悉的歌曲,那樣聽眾就可以跟著唱.
be familiar to 則是某物、某事為某人所熟悉：
例句：
The name seems familiar to me 相當(dāng)于I seem familiar with the name.這個(gè)名字我似乎是很熟悉的.