1.be responsible for
對(duì)……負(fù)責(zé)；負(fù)責(zé)某事
例句：
1）Do you want to be responsible for your own life decisions?
你是否真的想要為你自己的人生決定負(fù)責(zé)?
2）be responsible for sth.或 be responsible for doing sth.也可表示"負(fù)責(zé)(做)某事"
例：be responsible for sales 負(fù)責(zé)銷售
Our client wanted to be responsible for testing the application.
我們的客戶想要負(fù)責(zé)測(cè)試這個(gè)應(yīng)用程序.
He should be responsible for that.
他應(yīng)該對(duì)此事負(fù)有責(zé)任.
2.be responsible to do 負(fù)責(zé)做某事 ;對(duì)某人負(fù)責(zé)
例句1：They are to be responsible to you and are to perform all the duties of the Tent,but they must not go near the furnishings of the sanctuary or the altar,or both they and you will die.
他們要守所吩咐你的,并守全帳幕,只是不可挨近圣所的器具和壇,免得他們和你們都死亡.
例句2：But we just have to be responsible to ourselves.
但是,我們只需要對(duì)自己負(fù)責(zé).
-----to后面接人就表示“對(duì)……負(fù)責(zé)”,to后面接動(dòng)詞就表示“負(fù)責(zé)做……（事情）”