英語(yǔ)翻譯
According to the findings of Yamade,Sawaki and Hayami [5],the new antituberculous drug D-cycloserine
suppresses the decarboxylation and decomposition of tryptophan in cell-free preparations of bacterial enzymes
in lower concentrations than does isoniazid.The addition of pyridoxal or phosphopyridoxal restores the suppressed
processes.
These authors also showed that cycloserine forms complexes with vitamin Bs \x0c9
N.K.Kochetkov and his co-workers suggest that the antibacterial action of cycloserine is based on
disturbance of nitrogen metabolism as the result of the formation of azomethine compounds of cycloserine with
the pyridoxal coenzyme.In this connection it appeared to be of interest to study the influence of both cycloserine
itself and of other compounds with analogous functional groups on the process of transamination.
According to A.E.Braunshtein and M.M.Shemyakin [1],the process of transamination begins by the
formation of an azomethine complex of phosphopyridoxal-protein with an amino acid.It is,therefore,quite
possible that the distinctive amino acid cycloserine plays the role of an antimetabolite in the transamination
reaction.
In the present research we studied the effect on transamination of D,L-eycloserine and of three other
compounds obtained by N.K.Kochetkov and his co-workers:cyclothreonine(preparation KKh-ll),the dihydmchloride
of the ethyl ester of B -aminooxyalanine (preparation KKh-9) and the semihydmchloride of 8-aminooxyalanine
(preparation KKh-14).The effect of these compounds on the process of transamination was investigated in rat
liver homogenates,incubated with glutaminic and pyruvic acids.