個體最多有多少種HLA-DR基因?或者說,單個細胞表達多少種MHC II?
背景：來自wikipedia,In the Class-II locus,each person inherits one gene HLA-DRα (DRA1) and one or two genes HLA-DRβ (DRB1 and DRB3,-4 o -5).That means that one heterozygous individual can inherit 6 or 8 Class-II alleles,three or four from each progenitor.
問1：
wikipedia,In the Class-II locus,each person inherits one gene HLA-DRα (DRA1) and one or two genes HLA-DRβ (DRB1 and DRB4 o -5) or three genes (DRB1 and DRB2 and DRB3) .That means that one heterozygous individual can inherit 6 10 Class-II alleles,5 from each progenitor.
（當(dāng)同源染色體分別是DR3,DR5,DR6其中之一時,MHC II 基因為10個）
問2：DR2 單體基因型含有B2 和B5基因,細胞會否經(jīng)過重排最后只有B2 或者B5留在染色體上?另外,HLA的MHC II的3個基因座DP,DQ,DR會否重排最后只留下一個座的基因來翻譯MHC II?
問3：
我認為這篇wiki 和這篇nature上用allele這個詞沒用對
wiki ：one heterozygous individual can inherit 6 or 8 Class-II alleles
nature：DRB1,DRB5 and DQ alleles on DR2 haplotype in Caucasians.
等位基因才是allele,但是DRB1,DRB5 and DQ根本不等位,因此,這兩處的 alleles應(yīng)該用genes來表達,