The difficult course of the birth of Central Bank of America: Due to the frequently seen phenomenon that European Private Bank of controlling the country through their rights of monopoly in currency issuing. Since the birth of United State of America, whether there is a need to set up a national bank or to set up what kind of national bank had been long the core debating topic of the American financial industry. Countless of economic experts had had non stop debating over the issue. During this long period, from The First United States Bank in 1791 to 1816's The Second United States Bank, and finally now the matured US Federal Reserve Board. This paper mainly introduces the development course of the Central Bank of America.