Acetanilide chemical reaction control principle and experimental operation. And more familiar for the purification of solid organic recrystallization.
The principle is as aromatic amines and amino aromatic ring are easy to react, in organic synthesis to protect amino, often into the first acetyl acetanilide, and then the other reaction, and finally hydrolysis to remove acetyl.
Operation: 50mL round bottom flask, to prevent heart of the distilled aniline 10mL, 15mL glacial acetic acid and some zinc powder, and put on a fractionation column, insert the thermometer, with a branch out of the water tube steam phone and acetic acid. Round bottom flask was refluxed on low heat asbestos-line, keep the thermometer reading at 105 ℃ approximately 1h, the reaction of water and a small amount of acetic acid was distilled out, indicates that the reaction when the temperature drops have been completed, stirring the reactants under the hot poured into a beaker filled with 250mL of cold water, the cooling filtration, the crude product washed with cold water. The crude product moved 500mL beaker, if 300mL of water, home heating beaker to asbestos the crude product dissolved online, coolish the filtrate cooled acetanilide crystallization, filtration.不好意思。我說了不要用網(wǎng)上的翻譯。