句子主干是：It seems impossible for us to read anything
只不過(guò)后面的獨(dú)立主格部分比較繁瑣：without the mind making reference to the framework knowledge_____has already acquired.
至于空格出該怎么填,第一要明確這個(gè)末尾部分的謂語(yǔ)has already acquired是誰(shuí)發(fā)出的.這里對(duì)象只有mind思維和knowledge知識(shí),顯然是“大腦思維”獲得,而非“知識(shí)”獲得；所以這里的主客體關(guān)系是“大腦思維獲得知識(shí)”,再理解下填入it后句子如何分析：
without the mind making reference to the framework knowledge （it has already acquired）,
it指代mind,并且括號(hào)內(nèi)是以the framework knowledge 為先行詞的定語(yǔ)從句,所以這里其實(shí)是把that/which省略了（因?yàn)樵趶木渲凶鞯氖琴e語(yǔ)）
原句是：
It seems impossible for us to read anything without the mind making reference to the framework knowledge （which/that）it has already acquired.
翻譯：如果思維不能很好的與我們大腦所獲得的知識(shí)框架聯(lián)系起來(lái),似乎我們什么也讀不懂.